Importance Of Cell Biology - 1122 Words

For almost a year and a half now, I have entered a more intensive research environment by working as research associate in the LaBarge Lab with the intention of working towards curing breast cancer. My regular routine runs the gamut of activities expected in a cell biology lab: feeding, passaging, expanding, and freezing cell strains grown in our lab; FACS sorting cells based on lineage specific surface markers; immunofluorescence imaging; gene expression analysis. As a research associate, I also make stock solutions and provide support for the staff scientists, post-docs, and graduate students that work in the lab. I work to help them find the answers to the questions they wish to ask about the biological system that is the human breast,†¦show more content†¦And, just as importantly, I experienced the disappointment of failure. A multi-day assay shows equal activity for the control and the experimental samples, FACS sorting collects populations from a control and experiment al condition that have the same gene expression, or the repeat of an experiment shows a different activity result in the samples intended to be biological replicates, essentially calling for another repeat with better experimental technique or a rehash of experimental design. But, after each failure, I observed the ebb of active bench time during a re-evaluation of experimental approach, and a great flow forward of activity as soon as a new approach was determined, showing that failure should inspire new design and ideas rather than true dismay. Currently, I am helping with two projects that involve investigating the effects of a cell’s microenvironment on its phenotypic and molecular characteristics and how these changes relate to the greater onset of breast cancer in older women. 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The Rosewood Films Depictions of the Rosewood Massacre

Racial tension between African Americans and whites caused an excessive amount of violence in the city of Rosewood. Citizens of Rosewood, Florida were victims of racial violence in 1923, which lead to eight documented deaths in the city. The city of Rosewood took a turn for the worst on January 1, 1923 when Frances â€Å"Fannie† Taylor claimed that she was assaulted by an African American man who enter her home without invitation. Many of the African American families that became involved knew that Mrs. Taylor was not telling the truth. Fannie lied to the people of Rosewood to fabricate the truth of her having an affair with another man. The man that assaulted her was not an African American; it was Fannie Taylor’s lover. Because of the lie, the city of Rosewood was instantly torn into pieces. The Rosewood massacre was not a well known historical event. To bring awareness to an important part of African American history, John Singleton decided to create a motion picture based on the Rosewood events. The movie displays the town that was filled with racial prejudice. It shows the many injustice attacks on the African American community. John Singleton did an exceptional job bringing the horrific racist events of 1923 in Rosewood, Florida to the eyes of billions. In the movie, a fictional hero was created. His name was Mr. Mann. Mann helped save many blacks that had no idea as to what they should do. Mann helped the surviving members of the Carrier family, the women and

Significance of Virtualization, and Cloud Computing in Virgin Atlantic free essay sample

The main concerns of being the management student are to learn great management practices and system from various organizations. Practical implication of theories and practices gained from colleges or universities must be applied to the practical world. Our knowledge will be getting a platform when it is being implemented in a real world. Virgin Atlantic is one of the successful business organizations are operating multi function services. Virgin Atlantic Airways is one of the leading airlines in Europe introduced by Virgin Group collection of branded companies in 1984. Virgin Atlantic is centralized with UK operating 30 destinations all over the world with the 40 Aircrafts in operation. It is also extending its operation via code shares flight with various airlines including Singapore Airlines, Virgin Blue, Continental Airlines and All Nippon. Virgin Atlantic has earned huge amount of financial revenue through its cargo service from Asian subcontinent. Virgin Atlantic, being a part of Virgin Territory, is able to make a revolution in an aircraft industry. We will write a custom essay sample on Significance of Virtualization, and Cloud Computing in Virgin Atlantic or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page It is repeatedly won best airline awards in the past for several years, airlines is constantly using innovation as a most primary part of its strategic success. Virgin Atlantic is the UK’s largest airlines owned by private sectors and successfully introducing new systems, operations as well as services. Virgin Atlantic now introduces on 747 and Airbus A340 as aircrafts. The key to success of this organization is team work. Virgin has the power of skilled world leading team in manufacturing as well as IT section. The team keep focuses on the innovation consistently. Virgin Atlantic is considered as the best maintained innovation leader in airlines industry. The airline is committed to continue its innovation and to facilitate the passengers and customers with new introduced services in airlines business. It is challenging that can fight with the market competition. As per the airlines function, the main function of an airlines is to provide the transportation facilities to the passengers and to the customers. Basically, Virgin Atlantic is IATA participated airlines the sales of the seats is through the GDS systems. Virgin Atlantic and its management team works as a sovereign foundation of analytical input to the aviation and departmental affairs strategy developing function. It also develops systematic, short-term and long-term visions of the airlines. Virgin Atlantic management develops the structure of a company depending on analysis of air costs, traffic, fares, capacity, service, and financial information. As a growing airline it frequently monitors organizational developments and make sure that departmental policies lead to address those developments. The main functions of any aircraft are to provide the transport facilities to the people and passengers. Virgin Airlines represents the airlines industry it keep passenger connected to their precious functions, jobs, leisure, corporate relations and countries with which passengers are linked through companies, families and friends, The main motto of virgin is to touch on some features distressing the specific desires in the airline business, and some of willingness to the public who use virgin’s services. Virgin Atlantic is a member of a global aviation system, and it acts as to maintain the safety and security issue. Top management of Virgin Atlantic provides economic analyses for international route cases. As a main functional work, Virgin Atlantic analyzes and evaluates the competitive and public effect of airline bankruptcies and strikes. The airline administers the important air service programs including fare updates, cargo systems, refund and revalidation policies, public complaints and comments regarding the services. Like every business organization, there are mainly four main functions of that produces a complete circle and create an effective management. Without all four functions of management, there is no worth of airlines sustainability in a market. Basically the four functions Virgin Atlantic performs of are planning, organizing, controlling and leading. All those functions are key to success of Virgin Atlantic. The effective and efficient management function is the core examples applied in Virgin Atlantic. Managers of Virgin Atlantic are liable for supporting not only for the organizational growth and to achieve its entire goal. The management functions of Virgin Atlantic is also to help the employees growth and reach their goals concerning with companys success. Virgin Atlantic Airways is keep participating in preparation of making the rules, maintaining departmental functions on behalf of legislative proposals in consideration with a variety of economic issues impacting the airline industry, the program also includes small community based air service, aircraft access at slot-controlled airports, air transporter fitness and airline industry structural issues. Virgin Atlantic has a clear mission for its operation. Company is sensitive towards the Security, safety and consistent delivery. Company believes that those three aspects are the basic foundation of its operation and entire strategy. Mission Statement of Virgin Atlantic- â€Å"Safety, security and consistent delivery of the basics are the foundation of everything we do† Virgin Atlantic in its word the mission is divided into three forms: Mission 1- â€Å"To Grow a Profitable Airline† Mission 2- â€Å"Where people Love to Fly† Mission 3- â€Å"And Where People Love to Work† The strategy of a company for three years is to build up those basic foundations to maintain the service effective and efficient. The top management believe that those three factors lead an organization to sustain in the leisure markets. The main strategic objective of Virgin Atlantic is to capture the market leader position. Virgin is the brand name and it keeps trying to promote its brand value all over the world. In the company history, it struggled more to obtain this position for the past 25 years and now the main goal is to give a new taste to customer every year. The virgin brand believes that the consumer behaviour and preferences are keep changing. It innovate the product in a short period of time and to get success. The main strategic goal is to earn more customer satisfaction helps to earn brand image as well as goodwill. Company takes every competitor as a challenge and always prepared to corporately fight with them. In this context as per the company top management â€Å"Customer are the great entity and they are weapons for competitors† Virgin Atlantic makes every day a happier day. It is a tonic for the soul – delivering great product, and great experiences for customers all around the world. †- Dilys Maltby, Senior Partner, Circus Virgin Atlantic is taken as the successful airlines company in an aircraft industry. The management teams are skilled and intelligence that they driven airlines in a height of success. However, the company have some weaknesses and threats as well. The SWOT analysis of Virgin Atlantic is as below; Strength: First Largest Private Airlines in UK. Differentiation based on service, price and value. Wide diversification of Customers. Excellent Management Team. Well designed and strong organizational structure. Weaknesses: Underdeveloped channels i. e. practicing irrational premium economy class. Distribution system is not developed fluently. Centralized Market; Focused only in London. Unfavourable use of code- shares, alliance and partnerships Opportunity: Mergers and Alliances for the future. Use as a tourism development carrier. Increase the destinations throughout the Europe. Less number of competitors in a country. Asian Markets can be used as a destination. (Only few direct connections are available in Asian least developed countries) Threats: Terrorisms and frauds in the text of tourism domination. Unconsciousness towards the health program or a campaign. Online booking facilities of other airlines may results an unfair competition. Supply surplus lead to lose in revenue. The main weakness of Virgin Atlantic Airways is its distribution system. Airline is only appointing more on UK based companies. The company is centralized and more concentrating to develop inside the UK rather to expand the International flight. Asian and African market is more potential than European destination. It is not meeting the perfect level of competitive market. The fare is relatively higher in comparison to other airlines due to the low connecting network. The introduction of the premium economic class itself is a contradictory one. It clearly discriminates the consumer preferences. Business class passengers are de-motivated and it will be the major reason for revenue cuts in future. On the other hand, Potter’s Five forces model is the most useful tool in the text of market analysis of Virgin Atlantic. The virgin Atlantic is basically focusing on the UK, it has the great influence in UK market. The potential customers of Virgin Atlantic is UK customer prefer more Virgin Atlantic with respect to its reliability, accuracy and the durability in short connection services. However, as per the internal problem of British Airways and improved loyalty of Virgin the level of customers is dramatically increasing. Virgin Atlantic is still not capable to capture the global market and it is somehow difficult to win over the various renowned airlines operating multi destination service. Such as Air France, KLM, Lufthansa, British Airways in Europe, Etihad, Qatar, Thai, Cathay Pacific, Singapore, Quantas in Asia and middle east. American, Continental, United, Air Canada in America are amazingly doing well business. Competition with those carriers is like a nightmare to Virgin Atlantic. Potential Entrants such as low cost carriers and the budget airlines are providing the excellent service those customer beliefs. Customers are price and quality sensitive and for the Virgin Atlantic it is a real threat to overcome new entrants strengths. An organization then becomes successful when it improves its weaknesses to challenge competitors and to exceed their strength. There are various tools are in use to overcome the weaknesses. In the age of information technology, IT based software are more useful to support business process. Strategic Grid model is one of the most common tools in business organization that provides the information from various functional departments using IT. Basically strategic Grid model gives business organization a framework what should be the best. Namingly, strategic grid model supports an organization to improve its competitive advantage using four factors analysis i. e Support, Factory, Turnaround and strategy as well. Strategic grid model in Virgin Atlantic is useful that it supports to make a strategy using the information provided as a grid. Zachman Framework is on the other hand, is just like an operation of a business organization. It analyze and shows the framework whether the business changes should be accepted or not. It is a framework that shows the concrete analysis of Scope, model of business, technology model, detailed interpretation as well and functioning the system based on IT based program. Framework use an ER diagram, Data Flow Diagram, user interface etc. Basically, it is a system design leading to system development life cycle helps to identify the problem and to give a recommendation to the organization. Virgin Atlantic should need to decentralize its operation to keep business running that it needs to rely on information technology. Online fare is one of the greatest weaknesses of Virgin Atlantic that it should maintain the level of online based ticketing to meet the competitors strength. Virgin Atlantic also needs to understand that the revenue is generating in organization with support of IT. So, it needs to increase the IT budget meeting the global needs of customer. Virtualisation is the most appropriate Information system in this competitive world. Using the virtual information system makes people familiar with the airlines system, fares and the pricing. It will lead to maintain the bridge between various countries that will minimize the corporate distances. Virtualization allows agent to book online, pay online and check online. Traditionally, we used to go to airlines or an agent to make a reservation, booking and to buy a ticket. But now the time is changing, technologies are improving and people are more engaging. Virtualization leads to push an organization in a global market as well. We often think that computerized system will cut off the employment level and creates an unemployment level. But the virtualization increases the efficiency and effectiveness of an organization as well as it improves the level of awareness as well. Virtualization is most necessary to meet the level of competitive market. As we are familiar with Web based ticketing and the aircraft system that no one wants to waste their time if they easily get the service with a same price via web. Virtualization also controls the level of fraud and eliminates the errors and the mistakes as well. Virtual system gives a proper knowledge to the clients than they get from agents. Customer can directly interact with the airlines as it somehow does not require third parties. Being a part of aircraft industry, Cloud Computing is the most effective tool to develop an organizational strength of Virgin Atlantic. Mainly, cloud computing allows airline and its member to use the information system in demand. Introducing the cloud computing will give more confidential information and precious data to the management that will use as a tool to compete with other organizations. The system is most reliable that leads to reduce the failure in system and signal problems. Obviously, people are more sensitive and they valued the time emotionally. Cloud computing allows people to use the internet in a cloud as well. Information system on air then will make people informed every time whether they are within aircraft or whatever. Grid computing supports to enable virgin’s shared network computers to be pooled and provisioned on demand to meet the changing demands of customers as well as changing needs of business. Grid computing is cost effective that enables multiple applications to share computing infrastructure, resulting in much greater flexibility, power, cost, power, scalability, performance, and availability all of the various functions at the same time. Grid computing leads to eliminate the unwanted or problematic systems without interrupting the system that will give continuity in process. Grid computing itself monitors and administers the airlines database systems. In today’s global economic environment where the competition level cannot be compared, the demands are growing; preferences are changing and the willingness power of people also increasing. Technologies and information systems are facilitating to satisfy the customer needs and demands. Computer and business information system plays a key role to improve organizations efficiency and effectiveness. One of the most important aspects of business is its Computer Information System. The business future is uncertain without use of computer technologies. https://prezi.com/kxo12lodth_d/copy-of-virgin-atlantic-management-style/ https://ru.scribd.com/doc/60328463/Virgin-Strategy1 http://tdan.com/the-zachman-framework-an-introduction/4140 http://www.businessballs.com/free_SWOT_analysis_template.pdf http://www.quickmba.com/strategy/porter.shtml http://www.12manage.com/

Tchaikovskys Symphony No. 6 Essay Example

Tchaikovskys Symphony No. 6 Essay A Palette of Human Emotions By: Gunnar Moll Peter Illyich Tchaikovsky is one of the most famous Russian composers. He was born in Votkinsk on May 7, 1840 into a middle class family. His family greatly supported his musical interests. They gave him piano lessons and provided him with the instruction of music theory. Their move to St. Petersburg proved to be a significant milestone is Tchaikovsky’s life. It had set the course for Tchaikovskys progress and success in the musical world. From September of 1850 to May of 1859, Tchaikovsky attended the School of Jurisprudence.At this boarding school in St. Petersburg, he received an excellent education and further pursued his interest in music. During this time, he received piano lessons from Rudolf Kundinger, a well known piano teacher, and Luigi Piccioli, an Italian master. Both teachers profoundly influenced Tchaikovsky, especially Piccioli who was one of the first to recognize his talent. It was also at the boarding school that T chaikovsky discovered his sexual orientation. Signs of his homosexuality became apparent, although throughout his life, he tried to keep his homosexuality kept quiet for the risk of a scandal.More inner turmoil followed in 1854 when his mother died. He was so affected with her death that he wrote 26 years later: â€Å"Every moment of that appalling day is as vivid to me as though it were yesterday†. In 1862, Tchaikovsky enrolled in the St. Petersburg Conservatory to focus solely on music. He studied theory and composition, piano, flute and organ under his principal teachers, Anton Rubinstien and Nikolai Zaremba. He also began to compose his first prominent works such as the Characteristic Dances and the String Quartet in B-flat major.After his graduation in 1865, he met opposition with other nationalistic composers due to his studies with the western-oriented Rubinstien. Such disdain for Tchaikovsky’s works was met by a group of the most prominent Russian composers cal led â€Å"The Five†. It wasn’t until Tchaikovsky wrote his fantasy-overture Romeo and Juliet that he gained the appraise of â€Å"The Five†. As a mature composer in 1867, Tchaikovsky produced some of his best works: the Piano Concerto no. 1, Variations on a Rococco Theme for cello, and Swan Lake to name a few. It was also during these years that Tchaikovsky began to struggle more and more with is sexuality.Accepting his supposed orientation, he ironically became effectuated with the Belgain soprano Desiree Artot, claiming that she was the only women he had ever loved. However, their marriage was unsuccessful, leaving Tchaikovsky with feelings of great depression. It is commonly believed that these negative feelings actually enhanced Tchaikovsky’s creativity. He wrote very long, ambitious works such as his Violin Concerto in D Major which was deemed impossible to play at the time. He extensively traveled throughout Europe to compose and promote new works. He eventually went back to Russia to settle down.There, he was awarded a lifetime pension from the Tsar for writing pieces for him. With financial security, he could turn his attention to cultivating his social skills which he lacked. Although he hated public life, he worked on improving his conducting, teaching, and public speaking. Tchaikovsky died in St. Petersburg in 1893, nine days after the premiere of his 6th Symphony. His death has been widely attributed to suicide. The rumor goes that a cholera outbreak had polluted the water supply in St. Petersburg. One had to boil the water to ensure that it was sterile and free of disease.One night after a concert, Tchaikovsky decided against boiling his water and drank it, thus dying of cholera. The general plan of Tchaikovsky’s symphonies includes a very pessimistic first movement, a sad, peaceful second movement, an allegro movement (often in dance form) and a fourth movement full of vigor. His 6th symphony, the Pathetique, is an exception. The themes are broad, decorative, and striking. The orchestration is rich but without any attempt at spectacular effects. The last movement is slow and mournful, and recent research reveals the reason.The Pathetique was only partly finished when news spread of a homosexual encounter Tchaikovsky had with a fellow student. Some believe that the composer finished the symphony as a farewell to life. The scoring is for the standard symphonic orchestra with winds, brass, strings, timpani, and other percussion instruments. It was premiered in St. Petersburg with Tchaikovsky himself leading the orchestra. The 1st movement is in sonata form. The slow introduction to this symphony is unusual in that it begins in the subdominant key E minor, solemnly introduced by the bassoons.It modulates into B minor and the tempo increases for the principal subject. This theme is elaborated and developed, and a march-like motif forms a bridge passage leading to a climax. The strings then in troduce an amorous, song-like second subject in D major. The development section enters with a bang. This section brings no startling thematic growth or transformation, but is highly dramatic and effective nonetheless. A huge recapitulatory climax utilizing the full brass section announces the return of the principal subject. The amorous song is also restated and ends with another dying coda.A descending pizzicato bass provides a background for the brass, which bring the movement to a close. The 2nd movement is in ternary form. This movement begins like a typical Tchaikovsky waltz, except for the unusual feature of a 5/4 time signature broken into 2+3 beats per measure. The first theme in D major, is basically an upward scale with a triplet in the middle, which descends in a similar fashion. The trio begins in the relative minor full of dissonance which creates emotional tension. Tchaikovsky also includes various modulations, thus adding to the effect of the trio.The key of D major returns at the end of the trio, announcing the return of the first theme. The coda consists of the first theme in the bass, and fragments of the trio in the upper parts. The 3rd movement is basically a scherzo in ternary form. It opens in a playful moto perpetuo with the violins and woodwinds. The trumpets then enter with a motive of descending fourths, and a march rhythm takes over the moto perpetuo. This eventually leads on to a march in E major, introduced quietly by the clarinet. Following this is a disappearance of the main rhythm through a syncopated chordal theme.The first group of themes is restated, and the march returns triumphantly following a fanfare of trumpets. The march is then brought to a heroic conclusion in the coda. The finale, marked Adagio lamentoso, is in rondo form. This movement is quite unusual in that it lacks the complexity of the first and is very slow and mournful very uncharacteristic of a final movement. The movement’s principal subject is a d escending idea in B minor created by the criss-crossing of various instruments. The theme is repeated, but the accents are now played by the darker wind instruments like the bassoon.The second subject is introduced by the strings in D major which builds to a climax. The now powerful rhythm stops suddenly as the theme repeats and moves back to B minor. The coda is very long, and consists of the second theme harmonized in a similar way to the first, portraying despair and sorrow. The year in which Tchaikovsky wrote this symphony, 1893, was the year that Russia began to make amends with France. Russia ratified the Duple Alliance and signed a military accord with the French. However, these political events did not influence Tchaikovsky’s sixth symphony at all.The massive culmination of emotion in his sixth symphony stem from his personal experiences at the time. He wrote the symphony in bouts of extreme depression. He tore up many drafts of the score claiming that it was one of t he worst works he had ever written. Strangely, he obsessed over writing the symphony soon after. He was wholly occupied with the work, unable to tear himself away from it. Tchaikovsky’s 6th symphony became one of my favorite orchestral pieces after I played the second violin part in the Connecticut Youth Symphony last year.It is a very emotionally draining work requiring great stamina and energy from everyone. My favorite recording of it would be the one played by the Russian National Orchestra. They seem to capture every nuance of the human emotion from the brooding bassoon introduction to the bombastic march in the 3rd movement. In my opinion, the Symphony Pathetique isn’t a musical experience. It’s more of a reflection on what it is to be human. The symphony forces one to reconnect with joy and sorrow. It serves as a reminder that we are human and even the coldest person can still feel.